Sunday, September 8, 2024

Regulation Thermometry and the AlfaSight 9000 (BETA)

FOR INTERNAL USE ONLY- DO NOT PUBLISH

INTRODUCTION
In our constant search for the latest innovations in non-invasive health and medical advancements, HealthTech Reporter met with Alfa Thermodiagnostics, the developers of the ALFASIGHT 9000. 

TECH DESCRIPTION FROM THE WEBSITE:
The AlfaSight 9000 (also known as the ALFA System) is a robust, easy-to-use, and reproducible measurement system that utilizes streamlined infrared technology, artificial intelligence (AI) - and years of world-corroborated, accumulated data. It’s a whole-body, early-detection system that views a patient’s overall health while finding hidden issues and causes for many disease including pre-disease contributing factors. 





 According to the manufacturer, this diagnostic device may detect the following Organ Dysfunctions: 

- Diabetes and Pre-Diabetes (Pancreas)                        - Breast (Breast Health, Cystic Changes)

- Liver Disease and Function                                        - Endocrine Function (Pituitary/Thyroid/Ovary)

- Cardiac Function (Efficiency, Electrophysiology)    - Brain and Headache

- Dental Infections                                                        - Structural Integrity (Neuromuscular)

- Pulmonary Function                                                    - Viral and Bacterial Disease Monitoring


 In August of 2024, HealthTech Reporter conducted a private interview with Dr. Daniel Beilin (CTO & Founder) about establishing the science of Regulation Thermography and his ALFA System.  Dr. Beilin is an American specialist in alternative medicine for over 35 years. He has a neurophysiology, gastroenterology, and herbal sciences background. His first research at the age of 16 included his own laboratory at the UCLA Brain Research Institute and is now internationally recognized for his contributions to detection of the causes of cancer and immune dysfunction with cutting-edge precision-based European diagnostic tools. 


FROM DR. BEILIN'S INTERVIEW 

PHILOSOPHIES
I was six and a half years in academic medical research when I decided that conventional medicine was not really anything but a bunch of recipe books for treating individuals with the same diagnosis in the same way. Whereas (truth is), every individual is different; the same pneumonia patient can have a different etiology and a different organ involvement that helps to make the person vulnerable to that pneumonia (say) could be cancer as well. I wanted to explore the terrain, which means that our own physiology that is controlled by our autonomic nervous system, our metabolism, our environmental exposures to toxins, our diet-- all of these factors are forgotten in conventional medicine. When someone walks in with a particular disease, they only target the end stage symptom and thereby not really helping long term, they can save lives and surgeons can definitely do a good job of that. In the preventive world, there has to be an understanding of how to see things that are invisible, that are building and not quite as bad as would be seeable in an ordinary lab blood test. 

 My technology only vaguely overlaps acupuncture and Chinese medicine. It's more in line with neurology. The doctors that can best understand what we're doing by our device are nuclear medicine radiologists and cardiologists... because what we're actually doing is challenging the body and examining the responses to the challenge. By this, we can understand health in a whole new way. By looking at the body in a dynamic way, we are able to see the resilience of each organ system by inducing stress into the whole body with exposure to cool air. From here, we take a 'before and after' exposure measurement, then we're able to define where on the body are their non-ideal responses. 

HISTORICAL PATH OF THE APFASIGHT 9000
 
I started going to Germany in about 1979. And I studied in about 20 different clinics and hospitals in Germany, Austria, and Switzerland. As you may know, Germany has always integrated conventional medicine with alternative methods such as homeopathic medicine, herbal medicine and nutritional medicine. They are the most open-minded alongside being very science minded and very ordered in the way they think. 

 There was a Dr. Schwan(sp?) that invented this method. I explored his work through his students since he had died by the time I got there. One of them was a Dr. Rimar Boniss (sp?) who was an internist, and he told me about this technology. 

 To clarify, I did not invent the technology, but I improved it vastly to be more stable. The values that we acquire are more highly calibrated to the human body and more reproducible. After he came to me, he said, "I know the guy that is creating these devices, manufacturing the devices, so why don't you see if you can get it through the FDA and then you could distribute them and then educate doctors." So that's exactly what I did. 


I brought this device to FDA, cleared it with the Department of Radiological Devices (which is a pretty serious group), and then that company got sold off and it's not really manufactured anymore. I was told by leaders in the field, like Dr. Dietrich Klinghardt, that if I could manufacture or create my own device that would be improved, then he would endorse it. Then, we could start a whole new orientation to use this device as the prime initiatory clinical device since that means that every single patient that comes to a hospital or a clinic, if they're tested with this method. 

 This method digitizes skin temperatures. it's not falsely trying to look inside the body like an X-ray, but (instead) it's taking the skin's temperature and that the skin is all controlled by the sympathetic nerves that align with capillaries that open and close and let heat out or keep heat in. We're actually using the sympathetic nervous system and its connections through the spine and to the internal organs to get indirect readings of all the organ systems as well as tissue such as breasts, lymph and all kinds of thoracic syndromes and orthopedic problems. 

 It's a single 20-minute test. It involves taking the first measurement down to your waist, and then you have to remove your clothes from your waist up into your underwear so that you then become exposed to cool air for 10 minutes, which initiates a fight or flight reaction. Here, your blood shunts into your core, and to your head in order to prepare you for running away "from an enemy". 

 By looking at your own responses in about a hundred points that we measure, we're able to get some information about organ systems that are abnormal- those that are in their infancy stage up to their actual disease state. This opens up a whole new window of preventive care. 

 Five years ago, I presented at Beth Deaconess Hospital in Boston (Harvard) to 10 radiologists. One of them was the lead expert who reads all breast cancer research in radiology, trying to use computer assisted diagnostics and applying artificial intelligence to mammograms. She told me at the time that their computer assisted diagnosis was a complete failure and that the radiologist's eyes are still the most accurate assessment method. This uses up a lot of hours and manpower and very highly trained, trained people. She liked my device because it digitizes making objective, "and it looks like you have 13 algorithms that can depict building breast cancer." 

We planned a study on breast assessment in two categories. Ones that are not known, whether they're producing yet. A cancer is in differential carcinoma in situ two, which is a pre-cancer for most of its stages. It is not a cancer yet, but some oncologists believe differential carcinoma is a cancer. We can give additional information that can lead to better diagnostics. 

Within this time, the FDA declared our device, the AlfaSite 9,000 system as an ADJUNCT diagnostic system. This means that it doesn't tell you that you have cancer; if you have hepatitis (per se), it tells you that "you better do some imaging in this area-- or perhaps you ought to go out for a blood test here because we have the pattern of autoimmune thyroid like Hashimoto's, a Graves disease". 

 This kind of information gathered assists doctors in making better decisions on what to test for. It has a very high degree of accuracy for about 35 conditions. The test takes 20 minutes and certified technicians can be taught how to operate it in an hour- which includes generating a report based on all the data that's accumulated for proper interpretation. 

To date, we have 180 devices in 14 countries right now. I'm doing a new project with the biggest hospital in Asia, which is the Ames Hospital (just outside of Delhi with Dr. Prem, who is the lead physician). We are advancing into projects with our device that leads to a crucial step in medicine and prevention. This greatly affects women's health because of its high accuracy for breast assessment.

Sunday, August 25, 2024

A LEGACY OF COURAGE: ENTERING A WORLD IN BATTLE




Introduction: 
Captain Harry Schwartzbard

Family heirlooms may sometimes carry hidden treasures- the kind that could be a significant part of world history.  In the case of a unique news clipping from World War II, a unique feature interest story about a Jewish American Soldier received a major honor from battle at a time when Jews were at the height of persecution in Europe.

Published and written in the Yiddish language (often known to be an "old people's" language), the beneficiary held this special news clipping for over 80 years without any idea of its contents. Until recently, the beholder of this news excerpt had very little interest in getting the news piece translated due to the limited popularity of Yiddish-speaking/reading people around. Decades later, the news clip made its way to several historians who found significant value in the military success story.  It also spoke of cases and events of what would eventually become the future Jewish national Home (Israel).

Translated by: Shimmy Schwartz
An excerpt from the former YIDISHES ṬAGEBLAṬṬ (יידישעס טאגעבלאט = Jewish Daily News)



BROOKLYN JEWISH DOCTOR PRAISED FOR HIS HEROISM ON THE MARSHALL ISLANDS

1944 - Captain Harry Schwartzbard, a young Jewish doctor from Brooklyn, received widespread acclaim from the Associated Press for his heroic actions during the invasion of the Marshall Islands. Amidst the chaos of war, with people burning and bullets flying in all directions, Dr. Schwartzbard remained steadfast in his duty, tending to the injured and saving numerous lives. His bravery and selflessness in the face of extreme danger earned him well-deserved recognition. 

Mrs. Schwartzbard, residing at 1211 Avenue I in Brooklyn, recently gave birth to a baby two months ago. In a heartwarming moment on Christmas, her husband, Dr. Henry Schwartzbard, called from Honolulu and was able to hear their infant son cry for the first time over the telephone. Although he had yet to see a photo of their child, this moment brought joy to the new father. Mrs. Schwartzbard expressed her pride and happiness regarding the recognition her husband has received for his heroic actions. Dr. Schwartzbard, a graduate of City College and the University of Basel's medical program, was previously affiliated with Lincoln Hospital.



LEGACIES OF COURAGE:  ENTERING A NEW WORLD IN BATTLE


Family heirlooms may sometimes carry surprise hidden treasures- the kind that may hold a landmark in world history. A treasure trove of letters by the late Captain Harry Schwartzbard recently surfaced, passionately journaling life and times in the front lines of World War II to his recently-born and only son Robert between 1944-1945.  

Between the recklessly stored stack of letters was a mysterious news clipping that ignited the inspiring foundation behind “LEGACIES OF COURAGE”.  At a time when Jews in America were a small and underserved community, a local Brooklyn newspaper reported (in Yiddish) about our Jewish American Soldier who received a major military honor from battle- highlighting his unusual and courageous contribution during the height of Jewish persecution in Europe.  Such an award was a milestone for Jews at a time when prosperity in the new world for its people was most uncertain. After 80 years, the news clipping finally gained the attention of translators and several historians who found significant value as a military success story.


ARCHIVING 80-YEAR OLD LETTERS FROM THE WAR: PRESERVING HISTORICAL TREASURES

Dr. Bard recently brought to light a treasure trove of vintage photographs, news clippings and private letters from the front lines of WW2. These fragile reflections of world history are all that's left of the expressions of one Capt. Harry Schwartzbard to his baby son Robert (Bard) in the United States.  According to the archivalists at the AngioInstitute, such prints are so brittle and easily crumbled from the mere human touch.  Light and durable papers such as Moleskin and Crane were commonly used for air mailed letters back then- and are found to break apart under constant daylight and repeated photo flash after decades of being entoombed in storage.  The very oils of one's fingers and exposure to sunlight and incandescent light are enough to add to the deterioration process of these papers.  But thanks to current archival management techniques and storage tools, such articles and documents may stand to survive their next journey which involves scanners, photography and general handling from transcribers and publishers.



HISTORICAL SIGNIFICANCE OF MARSHALL ISLANDS

Invasion of the Marshall Islands (Operation Flintlock):  Jan. 31-Feb. 23, 1944 
Following the Gilbert Islands Campaign, the Marshall Islands Campaign consisted of two separate invasions of the Kwajalein and Eniwetok Atoll Groups.  Beginning on January 31, 1944 with the landings at Kwajalein, the campaign was declared secure at Eniwetok on February 22.  The landing forces met with light, but determined resistance, on both atolls.  The forces captured flight bases on the atolls which were crucial to the Mariana Islands Campaign.   (Source 1: US NAVY | Source 2: US ARMY)

After WWII, Nuclear testing at Bikini Atoll consisted of the detonation of 23 (or 24) thermonuclear weapons by the United States between 1946 and 1958 on Bikini Atoll in the Marshall Islands. Tests occurred at 7 test sites on the reef itself, on the sea, in the air, and underwater. The test weapons produced a combined yield of about 77 Mt of TNT in explosive power. After the inhabitants agreed to a temporary evacuation, to allow nuclear testing on Bikini, which they were told was of great importance to humankind, two nuclear weapons were detonated in 1946. About ten years later, additional tests with thermonuclear weapons in the late 1950s were also conducted. The first thermonuclear explosion was much more powerful than expected, and created a number of issues, but did demonstrate the dangers of such devices. (Source, Wikipedia)




EPILOGUE
In the post-war era of global migration to the US, it was common to “Americanize” lengthy or challenging names for easier social connectivity and community integration. By the next generation, the Schwartzbard family name was streamlined for this reason.  The infant in this story whose name is recognized as one of the most honored figures in diagnostic medicine and cancer imaging is Dr. Robert Bard.

In May of 2022, Dr. Robert Bard receives one of the highest national achievement awards commemorating his life's work in cancer imaging research and clinical care. The Ellis Island Medal of Honor is presented to those who advocate understanding, tolerance, and unity among Americans, transcending cultural, ethnic, and religious differences.  For almost four decades, Dr. Bard's commitment to the study of diagnostic imaging contributed to the advancement of non-invasive medical scanning technologies.  As a second generation medical professional and military veteran, Dr. Bard's pursuit to battle disease through research and patient care is a dedication to the life-saving legacy and worldly philosophies as that of his father, Dr. Schwartzbard during and after WWII.

Dr. Bard continues to run his active practice in NYC today. He maintains a pre/postop imaging facility for his cancer patients and others suffering from chronic disorders.  Dr. Bard is also the clinical director for Firefighters Against Cancer & Exposures, a national foundation in support of first responders health.  Moreover, as of August, 2024, his office has been confirmed to be the first official diagnostic  center, an early detection screening facility and recurrence detection site for the American Breast Cancer Foundation and the Male Breast Cancer Global Alliance.





Sunday, June 30, 2024

CANCER CARE SPOTLIGHT: THE BEDSIDE MANNER (from an interview with Dr. Rajiv V. Datta)


In our unending search for inspiring clinicians and health specialists in the life-saving battle against cancer, our next spotlight goes to Rajiv V. Datta, MD, Director of the Division of Surgical Oncology and Head and Neck Surgery.  Dr. Datta is also the Medical Director of the Mount Sinai South Nassau. Dr. Datta is one of the leading head and neck surgeons in the U.S. and an international leader in surgical oncology.

Dr. Datta spent almost three decades in cancer care. Though his field is the surgical aspect of cancer care, he is also the director of the cancer program, which means that he oversees a comprehensive treatment of the cancer patient.  This includes surgical, medical, radiation, research, support services, radiation oncology, radiology. According to Dr. Datta, overseeing the wide scope of the cancer care process "is most gratifying". Having combined with Mount Sinai has given him more abilities for better technology, better expertise and better research.

 

DIRECT FROM THE INTERVIEW - By: Dr. Datta

PART 1: EMPATHY AND THE HUMAN CONNECTION IS MEDICINE #1

Oftentimes, patients are scared (of and) from this disease.  There's a lot of fear of the unknown and in today's world there is so much out on internet that it does may not ever give you the right answers about a specific condition... but it's usually scary.  Most of what's out there are horrific treatments and a horrific end of the patient. Understanding this, my first objective when seeing the patient is to talk about EMPATHY and that we are in this together. I address [the dark] loneliness of having cancer by expressing that WE ARE both are facing this same issue. They have cancer and my job is to guide them through the appropriate therapy so that we both can beat this thing-  and that to me is most important. I start with emotional support because they're facing a frightening diagnosis is anxiety, sadness, even sometimes anger.

I always explain to my team that if a patient is angry, they're not angry at you, they're angry at the diagnosis.  Never get into arguments with the patient because they have cancer-- it's not a level playing field. Compassion should start at the front desk when they call. We should bring them calm down and trust because the patients all seek to feel cared for. It's not about a doctor's line of degrees and all big words. If I have not connected with the patient, why would they even trust what I'm saying? It's the human connection. They have to trust who I am before they can start believing all the fancy stuff I'm trying to do.

THWARTING STRESS: What are the things the most stressful? It's amazing that what I think may be the most stressful part of the diagnosis may not be the patient's stressful part. Part of connecting with the patient is finding and addressing what is causing the patient stress. This can be quite complexed. I take time to listen to their question and answers and concerns and I never interrupt them because patients are not experts. By the time they come to me, they've looked on the internet, they have had 10 people talk to everybody in the family is a doctor. Everybody's telling them what to do. My job is just to listen to them. What do they think is going on with them and what are they concerned about? And then one by one, I break down what's going on, what is the reality?

BREAK DOWN THE MYTHS: I can tell you after my talk that the majority keep the entire folder site to the side. The more compassionate care earns the kind of trust between physician and patient, allowing them to accept the treatment in a more positive way- making for better outcome overall. If a patient is dragged into a treatment, the mind body healing may not allow for a good outcome. And finally, you also have to preserve their dignity where cancer can often make them feel their most vulnerable.  I always sit down when I talk because I'm very tall (6'4")  so I always sit down so I don't look like a towering person.

This level of connection is critical in building teamwork with the patient. It doesn't help to have a patient 'yessing' me- I need them to actually understand what I'm saying. They actually ask me pertinent questions and not being just a robot. Sometimes I stop my talk halfway if I sense that they're not asking me the right questions. Even when they come for a followup, we first spend a few minutes talking about who they are and what's going on with them.

To me, this synergy building is a great journey, which I try to navigate them through to get the best possible outcome.




"When you have a diagnosis of Cancer your first thought is where do I go? What do I do?  Will I live or die? When my son was diagnosed with Cancer in 1974 and my mother Breast Cancer the same time fear almost took over.  When my son asked me what he did wrong I realized I had to get the answers. Their diagnosis prepared me for when I was diagnosed with Breast Cancer and asking the right questions. But more importantly was getting the right Doctor. When I met Dr Rajiv Datta, I knew immediately he was the answer-not just for me but for so many who had Cancer. I admire his honesty, his dedication to his craft and his kindness to me as a patient.  He showed me the courage I needed to keep going by telling me the straight facts. I put my life in his hands and continue to do so to this day.  His understanding of Cancer and people (including our families) never ceases to amaze me. There isn't a place I go or a person that I mention his name that hasn't heard of his compassion and respect. Dr Datta is a great man and a wonderful Doctor with a beautiful family."

- Geri Barish, President of The Hewlett House



Breast Cancer Incidence on Long Island: Environmental Impact
 A report by: Dr. Noelle Cutter (Molloy University) and Ben Honigsfeld

Breast cancer is a current health concern, affecting millions of women globally.  In 2023, it was the leading cause of death due to cancer in the United States (ref). While genetic factors and lifestyle choices play significant roles in its development, emerging evidence suggests that environmental exposures also contribute to breast cancer incidence rates. Long Island, New York, has garnered attention due to its elevated breast cancer rates compared to national averages, prompting investigations into the potential environmental factors driving this phenomenon. 

Whether environmental contaminants increase breast cancer risk among women on Long Island, NY, is unknown. In the early 1990s, breast cancer advocates petitioned the United States Congress to investigate the high rates of breast cancer on Long Island in the state of New York (1992-1996 117.8 per 100,000 in Nassau County, 113.6 in Suffolk county vs national average (NYS Cancer Registry, 2023). The resulting law led to the Long Island Breast Cancer Study Project (LIBCSP)--more than ten collaborative research projects designed to study the possible causes of this increased incidence of cancer. This project reported that there was no evidence that environmental exposures were responsible (ref, LIBCSP). However, the rate of BC on Long Island remains high compared to other regions in the United States (2016-2020 Nassau 145.9 and Suffolk 139.9) (NYS Cancer Registry, 2023). and has led to speculation that environmental risk factors remain an important cause of breast cancer. 


ENDOCRINE-DISRUPTING CHEMICALS (EDCS):
Endocrine-disrupting chemicals (EDCs) are natural or human-made chemicals that may mimic, block, or interfere with the body’s hormones, which are part of the endocrine system. These chemicals are associated with a wide array of health issues, including cancers (Safe, 2000). Endocrine disruptors are found in many everyday products, including some cosmetics, food and beverage packaging, toys, carpet, and pesticides. Some chemicals that act as flame retardants may also be endocrine disruptors. Long Island’s environment is full of potential sources of EDCs, which have been linked to an increase in breast cancer development. 

A study by Soto et al. (2015) highlighted the presence of EDCs such as bisphenol A (BPA) and phthalates in everyday consumer products, including plastics and personal care items. These chemicals can interfere with hormonal signaling pathways, such as the estrogen, androgen, and growth factor signaling pathways. EDCs such as BPA, phthalates, and certain pesticides can mimic estrogen's action by binding to estrogen receptors (ERs) and activating estrogen-responsive genes and turning on downstream transcription factors which are involved in pathways associated with many cancers, including breast cancer. The Androgen Signaling Pathway can also be impacted by EPCs.  Androgens, such as testosterone, play crucial roles in the development and maintenance of male reproductive tissues and secondary sexual characteristics. EDCs can disrupt androgen signaling by interfering with androgen receptor (AR) activation or inhibiting androgen synthesis. This disruption can impact reproductive health, development, and hormone-sensitive tissues in both males and females (Akdag et al., 2016). 

Additionally, the Growth Hormone/Insulin-like Growth Factor (GH/IGF) Signaling Pathways are critical regulators of growth, development, and metabolism. EDCs like polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) can interfere with GH/IGF signaling pathways, affecting cellular proliferation, differentiation, and apoptosis. Disruption of these pathways by EDCs may contribute to altered growth patterns and increased susceptibility to cancer and potentially increasing breast cancer risk. Moreover, Long Island's proximity to industrial sites and agricultural areas raises concerns about exposure to these environmental EDCs with studies suggesting a possible association between pesticide exposure and breast cancer incidence (Engel et al., 2017). Contact with these chemicals may occur through air, diet, skin, and water.

(See complete report)


CHANGES IN BREAST CANCER CARE IN NEW YORK DURING THE COVID-19 PANDEMIC   By:  Alexandra Fiederlein | Cheyenne Rosado | Noelle Cutter


Breast cancer is the second most common malignancy among women in the United States. As such, the COVID-19 pandemic has caused medical facilities to change their methods of operation since March of 2020, including changes in diagnosis and treatment plans. New York (NY) has an unusually high incidence of breast cancer. This study analyzed the effects of the COVID-19 pandemic on breast cancer care (BCC) in NY. Women in NY that were diagnosed with or in remission for breast cancer were asked to take an online, anonymous survey regarding their BCC experience. For patients in treatment, 26% of women wished they had greater emotional support or had a family member included in their appointments. 39% of women do not feel they are receiving as good of care as before, while 31% feel they are receiving the same level of care. Additionally, 41% of women feel they received the same level of care over telemedicine. 

Our data show a negative correlation between the quality of care received during the pandemic and the wish for more emotional support and inclusion of supportive members in the care process (nonsignificant). There was less of a negative correlation between the quality of telemedicine care received during the pandemic and the wish for more emotional support and inclusion of supportive members in the care process (nonsignificant). This indicates that most women lacking emotional support reported worse BCC experiences, and telemedicine use was not as troublesome to patients as the lack of emotional support. Most women in treatment and in remission reported negative feelings like fear when asked about their BCC experiences. Our data show the importance of emotional support for breast cancer patients and those in remission during the COVID-19 pandemic. Our work could also provide clinicians with the knowledge necessary on how breast cancer care should be handled in an evolving pandemic such as COVID-19.







A major concern is the presence of breast cancer in underserved communities, including those TOO YOUNG FOR A MAMMOGRAM.  Whereby the medical community touts the recommended (and legal/billable status) of getting a mammo scan should be between 40-50, what happens to the many women who do not fit this age criteria?  How would they even know to get checked without the support of their clinicians or an alarm from family history? Decades into the battle against breast cancer, clinicians and the public are much more educated about EARLY DETECTION, PREVENTION and the current protocols and modalities available to save lives.  Recent headlines on DENSE BREAST and the advancements in ULTRASOUND SCANNING supports a major part of this battle. SEE COMPLETE FEATURE


WATERBURY, Conn. (October 12, 2023) JOE CAPPELLO/ARE YOU DENSE? FOUNDATION RECEIVES KEY TO THE CITY FROM MAYOR O'LEARY
Waterbury celebrated a citywide Pink Out on Thursday, October 26th! Saint Mary’s Hospital Foundation has once again partnered with the City of Waterbury to recognize Breast Cancer Awareness. Waterbury Mayor Neil O’Leary, Saint Mary’s Hospital President, Kim Kalajainen and special guest Joe Cappello will address organizers and volunteers from the Waterbury Police and Fire Departments as well as the Education Department, area students and others at 11:00 a.m.  at Waterbury City Hall.  





PinkSmart NEWS: National Dense Breast Disclosure Law 9/10/2024

FOR IMMEDIATE RELEASE:

National Dense Breast Disclosure Law, takes effect on 9/10/2024

6/18/2024 - Hartford, CT.  The Are You Dense Foundation is proud to confirm the National Dense Breast Disclosure Law on September 10, 2024 at the Connecticut Legislative Office Building. This groundbreaking law aims to empower women by ensuring they receive crucial information about their breast density during mammography screenings.

Connecticut is taking the lead in championing breast density awareness, recognizing the importance of transparency and informed decision-making for women's well-being. The National Dense Breast Disclosure Law requires healthcare providers to inform patients about their breast density during mammography screenings. By providing this vital information, women can better understand their individual risk factors and seek appropriate medical care. Together, we will celebrate this historic moment and the power of knowledge in women's healthcare decisions.

This event marks a significant milestone in women's health.  According to co-founder and executive director Joe Cappello, "this law is a bold step in implementing this law is expected to set a national precedent...  in September, this law will become effective nationwide, ensuring that women across the country have access to this essential information.  This law showcases Connecticut's commitment to women's health and its determination to make a positive impact on a national scale. By raising awareness about breast density and empowering women with knowledge, lives can be saved and the overall well-being of women can be improved." 

This event is welcome to the public to attend. September 10, 2024 (11am - 1pm) at the at the Connecticut Legislative Office Building 300 Capitol Ave #5100, 2nd Floor, Hartford, CT. There will be guest speakers and a light lunch. For more info, visit: www.AreYouDense.org and www.AreYouDenseAdvocacy.org

 From the press room of:




REMEMBERING NANCY
6/15/2024- In celebration of the upcoming birthday of the late Dr. Nancy Cappello (Oct. 30), the ICRS (Integrative Cancer resource Society) gives honor to her courage and life-saving pursuits to bring global awareness about the risks of Breast Cancer from the link to dense breast tissue.  Dr. Cappello’s work to inform women about the risks of dense breast tissue led to density inform laws in 35 states.  Her advocacy also led to bringing clinical reform to earlier detection screening. According to Dr. Roberta Kline (Women's Health Digest medical publisher) and Dr. Leslie Valle- Montoya (ICRS exec. director), "...though we all know her passing to earmark a major movement in women's health, honoring the birthdate of such a figure posthumously (we feel) better resonates a more loving and eternal remembrance of message by breathing continued life to her legacy!"  (See original source: ITN NEWS)

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Thursday, June 13, 2024

Breast Cancer Incidence on Long Island: Environmental Impact

 A report by: Dr. Noelle Cutter (Molloy University) and Ben Honigsfeld

Breast cancer is a current health concern, affecting millions of women globally.  In 2023, it was the leading cause of death due to cancer in the United States (ref). While genetic factors and lifestyle choices play significant roles in its development, emerging evidence suggests that environmental exposures also contribute to breast cancer incidence rates. Long Island, New York, has garnered attention due to its elevated breast cancer rates compared to national averages, prompting investigations into the potential environmental factors driving this phenomenon. 

Whether environmental contaminants increase breast cancer risk among women on Long Island, NY, is unknown. In the early 1990s, breast cancer advocates petitioned the United States Congress to investigate the high rates of breast cancer on Long Island in the state of New York (1992-1996 117.8 per 100,000 in Nassau County, 113.6 in Suffolk county vs national average (NYS Cancer Registry, 2023). The resulting law led to the Long Island Breast Cancer Study Project (LIBCSP)--more than ten collaborative research projects designed to study the possible causes of this increased incidence of cancer. This project reported that there was no evidence that environmental exposures were responsible (ref, LIBCSP). However, the rate of BC on Long Island remains high compared to other regions in the United States (2016-2020 Nassau 145.9 and Suffolk 139.9) (NYS Cancer Registry, 2023). and has led to speculation that environmental risk factors remain an important cause of breast cancer. 

ENDOCRINE-DISRUPTING CHEMICALS (EDCS):
Endocrine-disrupting chemicals (EDCs) are natural or human-made chemicals that may mimic, block, or interfere with the body’s hormones, which are part of the endocrine system. These chemicals are associated with a wide array of health issues, including cancers (Safe, 2000). Endocrine disruptors are found in many everyday products, including some cosmetics, food and beverage packaging, toys, carpet, and pesticides. Some chemicals that act as flame retardants may also be endocrine disruptors. Long Island’s environment is full of potential sources of EDCs, which have been linked to an increase in breast cancer development. 

A study by Soto et al. (2015) highlighted the presence of EDCs such as bisphenol A (BPA) and phthalates in everyday consumer products, including plastics and personal care items. These chemicals can interfere with hormonal signaling pathways, such as the estrogen, androgen, and growth factor signaling pathways. EDCs such as BPA, phthalates, and certain pesticides can mimic estrogen's action by binding to estrogen receptors (ERs) and activating estrogen-responsive genes and turning on downstream transcription factors which are involved in pathways associated with many cancers, including breast cancer. The Androgen Signaling Pathway can also be impacted by EPCs.  Androgens, such as testosterone, play crucial roles in the development and maintenance of male reproductive tissues and secondary sexual characteristics. EDCs can disrupt androgen signaling by interfering with androgen receptor (AR) activation or inhibiting androgen synthesis. This disruption can impact reproductive health, development, and hormone-sensitive tissues in both males and females (Akdag et al., 2016). 

Additionally, the Growth Hormone/Insulin-like Growth Factor (GH/IGF) Signaling Pathways are critical regulators of growth, development, and metabolism. EDCs like polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) can interfere with GH/IGF signaling pathways, affecting cellular proliferation, differentiation, and apoptosis. Disruption of these pathways by EDCs may contribute to altered growth patterns and increased susceptibility to cancer and potentially increasing breast cancer risk. Moreover, Long Island's proximity to industrial sites and agricultural areas raises concerns about exposure to these environmental EDCs with studies suggesting a possible association between pesticide exposure and breast cancer incidence (Engel et al., 2017). Contact with these chemicals may occur through air, diet, skin, and water.


AIR & WATER POLLUTION:
Long Island's densely populated urban areas are susceptible to high levels of air pollution, including particulate matter and volatile organic compounds (VOCs), which have been implicated in breast cancer development (Hystad et al., 2013). Additionally, concerns have been raised about groundwater contamination from industrial activities and pesticide runoff from agricultural lands. A case control study investigating pesticide use on Long Island identified that women using higher amounts of pesticide in and around their homes had a greater than 30% increase in risk of developing breast cancer. In addition, use of most individual and combined lawn and garden pesticides examined by the study identified a consistent elevation in breast cancer risk (Teitelbaum et al., 2007). 

However, the lack of dose-response relationship and conflict of the LIBCSP study results indicates the need for additional research. In addition to pesticides, a major source of contamination is due to the Navy-Grumman groundwater plume. Beginning operation in the 1930s, the 600 acre Northrop Grumman-Bethpage Facility and Naval Weapons Industrial Reserve plant site was utilized for military industry and research until 1996 (DOJ, 2022). During this time, Northrop Grumman’s activities lead to the contamination of the soil and groundwater with volatile organic compounds, polychlorinated biphenyls, metals, and many others (NYSDOH, 2022). These contaminants were first detected in the 1970s, allowing for decades of unopposed groundwater, soil and air contamination. 

Furthermore, the New York Department of Health estimates that groundwater contamination reaches up to 750 feet deep, and stretches over 3800 acres (NYSDOH, 2022). This dumping took place on land now surrounded by residential neighborhoods, thus posing a major hazard to the community. As of March 2024, buried contaminants are still being discovered, with additional potential sources still expected to be present (DEC, 2024). 

There was also detection of similar contaminants at the Naval Weapons Industrial Reserve Plant in Calverton in eastern Long Island, which resulted in closure of all wells on the contaminated property in 2012 (NYSDOH, 2022). Amongst the contaminants identified as part of the Northrop-Grumman plume, concerns have been raised regarding 1,4 dioxane in particular, a solvent stabilizer rated by the EPA as a likely human carcinogen. In an evaluation of 4,400 water sources across the country, the EPA identified Long Island as having among the highest levels of 1,4 dioxane (EPA, 2021). In response, the Yale Superfund Research Center has initiated a series of 4 projects to measure the exposure to 1,4 dioxane and connection to adverse biological effects (Kim & Fortner, N.D.). 

In addition to spillage from Northrop-Grumman, the Hooker Chemical & Plastics Corp./Ruco Polymer Corp plant formerly located in Hicksville was discovered to have contaminated the groundwater with vinyl chloride, trichloroethylene, barium, cadmium, organic acids, and other compounds due to dumping practices. These activities were discovered in 1984 after several decades of operation, and groundwater cleanup is still underway (EPA, N.D.). Unfortunately, It is clear that Long Island has suffered decades of hazardous waste exposure through soil, water, and air. 

A study by Gammon et al. (2002) found an association between residential proximity to hazardous waste sites and increased breast cancer risk among Long Island women, highlighting the potential role of environmental pollutants in driving breast cancer incidence rates. Besides cancer, environmental pollution has also been linked to increased rates of cardiovascular, reproductive, neurological, gastrointestinal, respiratory, and developmental disorders among other complications (Shetty et al. 2023).

RADIATION EXPOSURE:
Long Island's history of nuclear facilities and radioactive waste sites raises concerns about radiation exposure and its impact on breast cancer risk. Namely, the Shoreham Nuclear Power Plant, decommissioned in 1994 before becoming fully operational due to public safety concerns. During the breakdown process, 5 million pounds of radioactive waste via 353 truckloads, as well as water barges to remove 560 irradiated fuel assemblies was required (NYT, 1994). In Upton, Suffolk County, Brookhaven National Laboratory experienced a tritium leak in 1998, leading to tritium in the groundwater above the state and federal drinking levels (Brookhaven Bulletin, 1998). This culminated in a shutdown of the High Flux Beam Reactor (ANS, 2022). The extent and harm of the leak remains a point of controversy, and has been designated as a superfund site by the EPA and is under periodic 5-year review (EPA, 2024). 

Irradiated surfaces were treated and the area remains at normal background levels according to state officials . While medical imaging and radiation therapy contribute to some extent, historical exposure to ionizing radiation from nuclear facilities may have long-term health consequences. A study by Boice et al. (2012) suggested an increased risk of breast cancer among individuals exposed to low-dose ionizing radiation, emphasizing the importance of monitoring and mitigating radiation hazards in the environment. The effects of ionizing radiation on the destabilization of DNA have been well documented, with research particularly emphasizing double strand breakage, and generation of reactive oxygen and nitrogen species (Helm & Rudel, 2020). 

(Click image for full view)

Furthermore, ionizing radiation has been found to cause epigenetic alterations, including alterations in DNA methylation and histone acetylation (Pogribny, 2019). with regards to breast cancer specifically, no association was found with high levels of UV radiation and overall breast cancer incidence (Gregoire et al., 2022) However, ionizing radiation has been demonstrated to increase the incidence of breast cancer in women in a dose-dependent manner, especially when the exposure occurs at a young age (Helm & Rudel, 2020).

Addressing the environmental impact on breast cancer incidence requires a collaborative effort involving community engagement, advocacy, and policy interventions. Clearly, more research is needed to ascertain the environmental impact on the increased incidence of breast cancer on Long Island.  By leveraging scientific research, community engagement, and policy advocacy, Long Island can work towards reducing breast cancer incidence rates and improving the overall health and well-being of its residents. 

References: https://prevention101.org/refs_6-13-2024-N.Cutter.html


CONTRIBUTORS

DR. NOELLE CUTTER is a professor of biology, ironman finisher, and advocate for dense breast screening.  United with an expanding research team dedicated to collecting data on women with dense breasts and screening options for these patients, her initiative aims to investigate and gather conclusive information about dense breasts in specific groups- including age, body mass index, and amount of physical activity and the underlying diagnostics of breast cancer tumors. This research program is under a partnership with Molloy College and Dr. Robert Bard, expert diagnostic cancer imaging specialist in NYC and other colleagues from the NY Cancer Resource Alliance. 

BENJAMIN HONIGSFELD began his interest in cancer research as part of the Advanced Science Research program in high school. Since then, Benjamin has contributed to research and publications regarding ovarian cancer, medulloblastoma, and brownfield site remediation, earning awards at LISEF, and MACUB. Benjamin is currently a third year medical student at Ben-Gurion University of the Negev and co-president of the internal medicine interest group.





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CHANGES IN BREAST CANCER CARE IN NEW YORK DURING THE COVID-19 PANDEMIC   By:  Alexandra Fiederlein | Cheyenne Rosado | Noelle Cutter

Breast cancer is the second most common malignancy among women in the United States. As such, the COVID-19 pandemic has caused medical facilities to change their methods of operation since March of 2020, including changes in diagnosis and treatment plans. New York (NY) has an unusually high incidence of breast cancer. This study analyzed the effects of the COVID-19 pandemic on breast cancer care (BCC) in NY. Women in NY that were diagnosed with or in remission for breast cancer were asked to take an online, anonymous survey regarding their BCC experience. For patients in treatment, 26% of women wished they had greater emotional support or had a family member included in their appointments. 39% of women do not feel they are receiving as good of care as before, while 31% feel they are receiving the same level of care. Additionally, 41% of women feel they received the same level of care over telemedicine. 

Our data show a negative correlation between the quality of care received during the pandemic and the wish for more emotional support and inclusion of supportive members in the care process (nonsignificant). There was less of a negative correlation between the quality of telemedicine care received during the pandemic and the wish for more emotional support and inclusion of supportive members in the care process (nonsignificant). This indicates that most women lacking emotional support reported worse BCC experiences, and telemedicine use was not as troublesome to patients as the lack of emotional support. Most women in treatment and in remission reported negative feelings like fear when asked about their BCC experiences. Our data show the importance of emotional support for breast cancer patients and those in remission during the COVID-19 pandemic. Our work could also provide clinicians with the knowledge necessary on how breast cancer care should be handled in an evolving pandemic such as COVID-19.

 

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